The First Relationship. In this contribution the intra-uterine life will be considered from a psychological perspective and described as a 'first relationship'. It is embedded in the motivations, wishes and expectations of the parents and the culture, as well as in the vegetative resonance offered by the maternal environment (positive or negative). The prenatal child takes part in this relation dynamic and learns from it. Basic bonding patterns get deeply stored in the developing organism and especially the brain. The relation with the mother is a vegetative-organismic one and cannot be described alone in a Me-You-terminology. We see the prenatal relationship as a 'bonding' and name the particularities: the contact via chemical-emotional exchange processes, the importance of touch, sound and vibration, conscious and unconscious communication, as well as the (mutual) dependence. The psychotherapeutic approach of Psychodynamic Bodytherapy follows these characteristics and postulates that prenatal psychopathology is based on bonding deficits in the area of containment, safety, continuity and space. The last part of this article deals with the most important treatment principles of prenatal bonding deficits. Essential is the resonating relationship with the therapist.